CDll/CDlS-Independent Neutrophil Adherence to Laminin Is Mediated by the Integrin VLA-6
نویسنده
چکیده
Regulated adherence of polymorphonuclear leukocytes (PMNs) to endothelium and subendothelial matrix is a critical event for PMN localization at and migration into inflammatory sites. We previously reported that human PMNs stimulated in vitro adhere to laminin, the major glycoprotein of mammalian basement membrane, by both C D l l /CD18 (pz integrin)-dependent and CD11 /CD18-independent mechanisms. This C D l l /CD18-independent adherence is inhibited by monoclonal antibodies (MoAbs) directed against the p1 subunit of integrins (very late antigens "1). The specific PMN VIA receptor responsible for stimulated CD11 /CD18independent PMN adherence to laminin was not elucidated. We show here that this C D l l /CDl&independent adherence is mediated by a member of the p1 integrins, VIA-6. MoAbs
منابع مشابه
CD11/CD18-independent neutrophil adherence to laminin is mediated by the integrin VLA-6.
Regulated adherence of polymorphonuclear leukocytes (PMNs) to endothelium and subendothelial matrix is a critical event for PMN localization at and migration into inflammatory sites. We previously reported that human PMNs stimulated in vitro adhere to laminin, the major glycoprotein of mammalian basement membrane, by both CD11/CD18 (beta 2 integrin)-dependent and CD11/CD18-independent mechanism...
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